事業内容 Description Of Business




  1. 2006年
  2. Shimoda H., Ski E., Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complemant. Altern. Med. 6:9 (2006).
  3. Shimoda H., Tanaka J., Yamada E., Morikawa T., Kasajima N., Yoshikawa M. Anti type I allergic property of Japanese butterbur extract and its mast cell deglanulation inhibitory ingredients. J. Agric. Food Chem. 54, 2915-20 (2006).
  4. 2007年   
  5. 下田博司,田中潤司,関 あずさ,本田晴哉,赤荻誠一郎,小松原博文,鈴木信夫,亀山眞由美,田村 理,村上啓寿 α-リポ酸の製造工程で生成する重合物の安全性と構造解析 食衛誌 48, 125-31 (2007).
  6. Tanaka J., Shan S.-J., Kasajima N., Shimoda H. Suppressive effect of defatted kiwi fruit seed extract on acute inflammation and skin pigmentation. Food Sci. Techonol. Res. 13, 310-4 (2007).
  7. 2008年
  8. Shimoda H., Tanaka J., Kikuchi M., Fukuda T., Ito H., Hatano T., Yoshida T. Walnut polyphenols prevent liver damage induced by carbon tetrachloride and D-galactosamine: hepatoprotective hydrolyzable tannins in kernel pellicles of walnut. J. Agricul. Food Chem. 56, 4444-9 (2008).
  9. 2009年
  10. Shimoda H., Tanaka J., Kikuchi M., Fukuda T., Ito H., Hatano T., Yoshida T. Effect of polyphenol-rich extract from walnut on diet-induced hypertriglyceridemia in mice via enhancement of fatty acid oxidation in the liver. J. Agricul. Food Chem. 57, 1786-92 (2009).
  11. Tanaka K., Nishizono S., Tamaru S., Kondo M., Shimoda H. Tanaka J., Okada T. Anti-obesity and hypotriglyceridemic properties of coffee bean extact in SD rats. Food Sci. Technol. Res. 15, 147-52 (2009).
  12. Shimoda H., Tanaka J., Takahara Y., Takemoto K., Shan S.J., Su M.H. The hypocholesterolemic effects of Cistanche tubulosa extract, a Chinese traditional clued medicine, in mice. Am. J. Chin. Med. 37, 1125-38 (2009).
  13. 下田博司 コメ由来スフィンゴ糖脂質の作用 細胞 41 (5), 203-205 (2009).
  14. 2010年    
  15. Tamura S., Yan K., Shimoda H., Murakami N. Anthocyanins from Oryza sativa L. subsp. indica. Biochem. System. Ecology. 38, 438-440 (2010).
  16. Shimoda H., Shan S. J., Tanaka J., Seki A., Seo J. W., Kasajima N., Kasajima N., Tamura S., Ke Y., Murakami N. Anti-inflammatory properties of red ginger (Zingiber officinale var. Rubra) extract and suppression of nitric oxide production by its constituents. J. Med. Food 13, 156-62 (2010).
  17. Shimoda H., Tanaka J., Shan S. J., Maoka T. Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules. J. Pharmacy Pharmacol. 62, 1137-45 (2010).
  18. 2011年
  19. Shimoda H., Nakamura S., Morioka M., Tanaka J., Matsuda H., Yoshikawa M. Effect of cinnamoyl and flavonol glucosides derived from cherry blossom flowers on the production of advanced glycation end products (AGEs) and AGE-induced fibroblast apoptosis. Phytotherapy Res. 25, 1328-35 (2011).
  20.  Tanaka J., Nakanishi T., Ogawa K., Tsuruma K., Shimazawa M., Shimoda H., Hara H. Purple rice extract and anthocyanidins of the constituents protect against light-induced retinal damage in vitro and in vivo. J. Agric. Food Chem. 59, 528-36 (2011).
  21. 2012年
  22. Tanaka J., Nakamura S., Tsuruma K., Shimazawa M., Shimoda H., Hara H. Purple rice (Oryza sativa L.) extract and its constituents inhibit VEGF-induced angiogenesis. Phytotherapy Res. 25, 214-22 (2012).
  23. Shimoda H., Shan S.H., Tanaka J., Maoka T., Beta-Cryptoxantin suppressed UVB-induced melanogenesis in mouse: involvement of the inhibition of prostaglandin E2 and melanocyte-stimulating hormone pathway. J. Pharmacy Pharmacol. 64, 1165-76 (2012).
  24. Shimoda H., TerazawaS., Hitoe S, Tanaka J, Nakamura S., Matsuda H., Yoshikawa M. Changes in ceramides and glucosylceramides in mouse skin and human epidermal equivalents by rice-derived glucosylceramide. J. Med. Food 15, 1064-72 (2012).
  25. 下田博司 コーヒー生豆およびクルミ種皮の肝保護・脂肪肝抑制成分 Foods & food ingredients of Japan 217 (1), 52-59 (2012).
  26. 2013年
  27. Tanaka J., Nakanishi T., Shimoda H., Nakamura S., Tsuruma K., Shimazawa M., Matsuda H., Yoshikawa M, Hara H. Purple rice extract and its constituents suppress endoplasmic reticulum stress-induced retinal damage in vitro and in vivo. Life Sci. 92, 17-25 (2013).
  28. Tanaka J., Kadekaru T., Ogawa K., Hotoe S., Shimoda H., Hara H. Maqui berry (Aristoterlia chinensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light. Food Chem. 139, 129-137 (2013).
  29. 2014年
  30. Shimoda H., Nakamura S., Hitoe S., Terazawa S., Tanaka J., Matsumoto T., Matsuda H. Anti-adipogenic polyphenols of water shield suppress TNF-alpha-induced cell damage and enhance expression of HAS2 and HAPB2 in adiponectin treated dermal fibroblasts. Natur. Products Chem. Res. 2:5 (2014).
  31. Nakamura S., Tanaka J., Imada T., Shimoda H., Tsubota K. Delphinidin 3,5-O-digulucoside, a constituent of the maquiberry (Aristotelia chilensis) anthocyanin, restores teat secretion in a rat dry eye model. J. Functional Foods 10: 346-354 (2014).
  32. 2015年
  33. Shimoda H., Hitoe S., Nakamura S., Matsuda H. Purple tea and its extract suppress diet-induced fat accumulation in mice and human subjects by inhibiting fat absorption and enhancing hepatic carnitine palmitoyltransferase expression. Int. J. Biomed. Sci. 11, 67-75 (2015).
  34. 2016年
  35. Asahi T., Wu Xiaohong, Shimoda H., Harada E., Kanno T., Nakamura Y., Kato Y., Osawa T. A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation related DNA halogenation. Biosci. Biothechnol. Biochem. 80 313-317 (2016).
  36. Toda K., Takeda S., Hitoe S., Nakamura S. Matsuda H., Shimoda H. Enhancement of energy production by black ginger extract containing polymethoxy flavonoids in myocytes through improving glucose. J. Natur. Med. 70: 163-172 (2016).
  37. Toda K., Hitoe S., Takeda S., Shimoda H. Black ginger extract increases physical fitness performance and muscular endurance by improving inflammation and energy metabolism. Helioyon 2: e00115 (2016).
  38. Toda K., Kohatsu M., Takeda S., Hitoe S., Shimizu N., Shimoda H. Enhancement of physical fitness by black ginger extract rich in polymethoxyflavones: a double-blind randomized crossover trial. Integrative Mol. Med. 3, 628-634 (2016).
  39. 2017年
  40. Moon S.H., Kim D., Shimizu N., Okada T., Hitoe S., Shimoda H., Ninety-day oral toxicity study of rice-derived γ-oryzanol in Sprague-Dawley rats. Toxicol. Reports, 4, 9-18 (2017).
  41. Shimoda H. et al. Suppressive efect of titerpenoids and a favonol gycoside in saberry etract on crbacol-induced cntraction of badder sooth mscle and TGF-beta-induced cntraction of cllagen gel containing bladder smooth muscle cells. J. Function. Foods, 31, 152-159 (2017).
  42. Hirano M., Takeda S., Hitoe S., Shimoda H. Luteorin-rich chrysanthemum flower extract suppresses baseline serum uric acid in Japanese subjects with mild hyperuricemia. Integrative Mol. Med., 4 (2), 1-5 (2017).
  43. Hitoe S., Shimoda H. Seaweed fucoxanthin supplementation improves obesity parameters in mildly obese Japanese subjects. Functional Foods Health and Disease, 7 (4), 246-262 (2017).



    1.下田博司 第2章 α-リポ酸のダイエット効果,機能性化粧品IV 正木 仁監修 シーエムシー出版社 pp.234-240 (2006).

  1. 下田博司 第7節 アンチエイジング素材としてのフィトケミカルズ,アクティブシニア社会の食品開発指針 サイエンスフォーラム社, 津志田藤二郎ら編集 pp. 99-105 (2006).
  2. 下田博司 植物ポリフェノール含有素材の開発-その機能性と安全性- ソバ 96-101, 月見草 278-282, コーヒー生豆(クロロゲン酸)183-188, フキ189-194 (2007).
  3. 金森拓也,下田博司3編 企業編 肥満予防食品と開発動向 オリザ油化㈱ 大澤俊彦監修 シーエムシー出版社 pp. 278-284 (2007).
  4. Shimoda H. Food-derived materials improving skin cell health for smoother skin. Nutritional Cosmetics, Edited by Tabor A. and Blair R. pp. 365-382 Elsevier (2009).
  5. Ibid, Shimoda H. Natural products supporting the extracellular matrix: rice ceramide and other plant extracts for skin health. pp. 319-334.
  6. 下田博司 5 サクラ 糖化による疾患と抗糖化食品・素材 米井嘉一監修 シーエムシー出版社 pp. 195-200 (2010).
  7. Shimoda H. 28 Anti-inflammatory properties of Zingiber officinale var. Rubra (Red ginger extract). Arthritis, Edited by Bagchi D. and Moriyama H. pp.409-418 CRC Press. (2011).
  8. 下田博司 第15章サクラの抗糖化活性成分 薬用食品の開発II 吉川雅之,村岡修監修 シーエムシー出版社 pp. 179-186 (2012).
  9. 下田博司 第19章 骨および関節疾患対応素材 温州ミカン,赤ショウガ 機能性食品・素材と運動療法 大澤俊彦,佐藤祐三監修 シーエムシー出版社 pp. 152-161 (2012).
  10. 下田博司 クロロゲン酸類 ポリフェノール 機能性成分研究開発の最新動向 波多野 力,下田博司 監修 シーエムシー出版社 pp. 272-279 (2016).
  11. Shimoda H. 7. Antiobesity profile of green coffee extract. Green coffee bean extract in human health. CRC Press (2016).


  • 下田博司,白崎知美,笠島直樹,金田 幸 カカオハスク抽出物の脂肪細胞に及ぼす作用 日本生薬学会年会 (2005).
  • 下田博司ら カカオハスクから得られたテオブロミン分画およびポリフェノール分画の脂肪細胞に対する作用 食品科学工学会 (2006).
  • 下田博司,白崎知美,笠島直樹,金田 幸 カカオハスク抽出物の脂肪細胞に及ぼす作用 日本生薬学会年会 (2005).
  • 下田博司ら カカオハスクから得られたテオブロミン分画およびポリフェノール分画の脂肪細胞に対する作用 食品科学工学会 (2006).
  • 下田博司, 中村誠宏, 森岡 誠, 松田久司 サクラ(Prunus lannesiana Wils. cv. sekiyama)花部の抗糖化作用成分 日本生薬学会大会(2010).
  • 下田博司,田中順司 ヤエザクラ花部抽出物および含有成分の抗糖化作用 日本栄養・食糧学会(2011).