事業内容 Description Of Business


ブロッコリー抗腫瘍, 抗カルボニル化

1)Suzuki R., Kohno H., Sugie S., Okada T., Tanaka T. Preventive effects of powdered broccoli sprout on azoxymethane-induced rat colonic aberrant crypt foci. J. Toxicol. Pharmacol. 17, 119-126 (2004).

2)Hirano M., Takeda S., Hitoe S, Shimoda H. Glucosinolates and isothiocyanates from broccoli seed extract suppress protein glycation and carbonylation. Functional Foods Health and Disease, 8, 35-48 (2018).

シソの実抗アレルギーYamamoto H., Sakakibara J., Nagatsu A., Skiya K. Inhibitors of arachidonate lipoxigenase from defatted perilla seed. J. Agric. Food Chem. 46, 862-865 (1998).
フキ抗アレルギーShimoda H., Tanaka J., Yamada E., Morikawa T., Kasajima N., Yoshikawa M. Anti type I allergic property of Japanese butterbur extract and its mast cell deglanulation inhibitory ingredients. J. Agric. Food Chem. 54, 2915-2920 (2006).
新規成分Yoshikawa M., Morikawa T., Tanaka J., Shimoda H. Medicinal food stuffs. XXXII. Novel sesquiterpene glycoside sulfate, fukinoside A, with antiallergic activity from Japanese butterbur (Petasites Japonicus) Heterocycles, 68, 2335-2342 (2006).
α-リポ酸重合物の安全性1) 下田博司,田中潤司,関 あずさ,本田晴哉,赤荻誠一郎,小松原博文,鈴木信夫,亀山眞由美,田村 理,村上啓寿 α-リポ酸の製造工程で生成する重合物の安全性と構造解析 食衛誌 48, 125-131 (2007).
抗肥満2) 下田博司 第2章 α-リポ酸のダイエット効果,機能性化粧品IV 正木 仁監修 シーエムシー出版社 pp.234-240 (2006).
キウイ種子抗炎症,美白Tanaka J., Shan S.-J., Kasajima N., Shimoda H. Suppressive effect of defatted kiwi fruit seed extract on acute inflammation and skin pigmentation. Food Sci. Techonol. Res. 13, 310-314 (2007).
クルミポリフェノール肝保護Shimoda H., Tanaka J., Kikuchi M., Fukuda T., Ito H., Hatano T., Yoshida T. Walnut polyphenols prevent liver damage induced by carbon tetrachloride and D-galactosamine: hepatoprotective hydrolyzable tannins in kernel pellicles of walnut. J. Agric. Food Chem. 56, 4444-4449 (2008).

Shimoda H., Tanaka J., Kikuchi M., Fukuda T., Ito H., Hatano T., Yoshida T. Effect of polyphenol-rich extract from walnut on diet-induced hypertriglyceridemia in mice via enhancement of fatty acid oxidation in the liver. J. Agric. Food Chem. 57, 1786-1792 (2009).

下田博司 コーヒー生豆およびクルミ種皮の肝保護・脂肪肝抑制成分 Foods & food ingredients of Japan 217 (1), 52-59 (2012).

生コーヒー豆抗肥満Shimoda H., Ski E., Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complemant. Altern. Med. 6:9 (2006).
Tanaka K., Nishizono S., Tamaru S., Kondo M., Shimoda H. Tanaka J., Okada T. Anti-obesity and hypotriglyceridemic properties of coffee bean extact in SD rats. Food Sci. Technol. Res. 15, 147-152 (2009).
カンカコレステロール低下Shimoda H., Tanaka J., Takahara Y., Takemoto K., Shan S.J., Su M.H. The hypocholesterolemic effects of Cistanche tubulosa extract, a Chinese traditional clued medicine, in mice. Am. J. Chin. Med. 37, 1125-1138 (2009).

1) 下田博司 コメ由来スフィンゴ糖脂質の作用 細胞 41 (5), 203-205 (2009).
2) Shimoda H. Natural products supporting the extracellular matrix: rice ceramide and other plant extracts for skin health. Nutritional Cosmetics, Edited by Tabor A. and Blair R. pp. 319-334 Elsevier (2009).

3) Shimoda H., TerazawaS., Hitoe S, Tanaka J, Nakamura S., Matsuda H., Yoshikawa M. Changes in ceramides and glucosylceramides in mouse skin and human epidermal equivalents by rice-derived glucosylceramide. J. Med. Food 15, 1064-72 (2012).

赤ショウガ抗炎症1) Shimoda H., Shan S. J., Tanaka J., Seki A., Seo J. W., Kasajima N., Kasajima N., Tamura S., Ke Y., Murakami N. Anti-inflammatory properties of red ginger (Zingiber officinale var. Rubra) extract and suppression of nitric oxide production by its constituents. J. Med. Food 13, 156-162 (2010).
2) Shimoda H. 28 Anti-inflammatory properties of Zingiber officinale var. Rubra (Red ginger extract). Arthritis, Edited by Bagchi D. and Moriyama H. pp.409-418 CRC Press. (2011).
黒米成分研究1) Tamura S., Yan K., Shimoda H., Murakami N. Anthocyanins from Oryza sativa L. subsp. indica. Biochem. System. Ecology. 38, 438-440 (2010).

1) Tanaka J., Nakanishi T., Ogawa K., Tsuruma K., Shimazawa M., Shimoda H., Hara H. Purple rice extract and anthocyanidins of the constituents protect against light-induced retinal damage in vitro and in vivo. J. Agric. Food Chem. 59, 528-36 (2011).
2) Tanaka J., Nakamura S., Tsuruma K., Shimazawa M., Shimoda H., Hara H. Purple rice (Oryza sativa L.) extract and its constituents inhibit VEGF-induced angiogenesis. Phytotherapy Res. 25, 214-22 (2012).

3)Tanaka J., Nakanishi T., Shimoda H., Nakamura S., Tsuruma K., Shimazawa M., Matsuda H., Yoshikawa M, Hara H. Purple rice extract and its constituents suppress endoplasmic reticulum stress-induced retinal damage in vitro and in vivo. Life Sci. 92, 17-25 (2013). 

4)Shimoda H., Aitani M., Tanaka J. Hitoe S. Purple rice extract exhibits preventive activities on experimental diabetes models and human subjects. J. Rice Res. 3:2 (2015). 

フコキサンチン美白, 抗肥満

1) Shimoda H., Tanaka J., Shan S. J., Maoka T. Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules. J. Pharmacy Pharmacol. 62, 1137-1145 (2010).

2) Hitoe S., Shimoda H. Seaweed fucoxanthin supplementation improves obesity parameters in mildly obese Japanese subjects. Functional Foods Health and Disease, 7 (4), 246-262 (2017).


1) 糖化による疾患と抗糖化食品・素材 米井嘉一監修 シーエムシー出版社 pp. 195-200 (2010).

2) Shimoda H., Nakamura S., Morioka M., Tanaka J., Matsuda H., Yoshikawa M. Effect of cinnamoyl and flavonol glucosides derived from cherry blossom glowers on the production of advanced glycation end products (AGEs) and AGE-induced fibroblast apoptosis. Phytotherapy Res. 25, 1328-35 (2011).

3) Matsuyama A., Kikuchi M., Shimoda H. Effect on Skin Condition by 8-week Ingestion of Standardized Cherry Blossom Flower Extract (Sakura Extract-P). Int. J. Biomedical Sci., 14, 12-19 (2018).

美容素材(総合)美容Shimoda H. Food-derived materials improving skin cell health for smoother skin. Nutritional Cosmetics, Edited by Tabor A. and Blair R. pp. 365-382 Elsevier (2009).

1) Toda K., Hitoe S., Takeda S., Shimizu N., Shimoda H. Passionflower extract induces high-amplitude rhythms without phase shift in the expression of several circadian clock genes in vitro and in vivo. Int. J. Biomedical Sci., 13, 84-92 (2017).

2) Takara T., Yamamoto K., Suzuki N., Hirano M., Shimizu N., Shimoda H. Passionflower extract improves diurnal quality of life in Japanese subjects with anxiety: A randomized, placebo-controlled, double-blind trial Functional Foods Health and Disease, 9, 312-327 (2019).


Shimoda H., Takeda S., Takarada T., Kato Y., Shimizu N., Toda K., Nakamura M., Handa H.,Nakamura S., Matsuda H. Hydroxypterocarpans with estrogenic activity in Aguaje, the fruit of Mauritia flexuosa (Peruvian moriche palm). Bioactive Compounds in Health and Disease, 2(3): 64-76 (2019). 


1) Takeda S., Shimoda H., Takarada T. Imokawa G. Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents. Plos one, 13 (10): e0205061 (2018).

2) Shimoda H., Tanaka J., Zaiki K., Nakaoji K. Tiliroside, a constituent of strawberry seeds, slightly enhances hyaluronan production via hyaluronan synthase 2 expression in mouse skin and human fibroblasts. Int. J. Biomedical Sci., 15, 24-31 (2019).


Moritani C., Kawakami K., Fujita A., Kawakami L., Shimoda H., Hatanaka T., Tsuboi S. Isolation of activating factors of serotonin N-acetyltransferase from rice peptides. J. Functional Foods, 41, 148-154 (2018).


1) Shimoda H., Takeda S., Shimizu N., Hirano M. Hitoe S. Suppressive effect of triterpenoids and a flavonol glycoside in seaberry extract on carbacol-induced contraction of bladder smooth muscle and TGF-beta-induced contraction of collagen gel containing bladder smooth muscle cells. J. Function. Foods, 31, 152-159 (2017).

2) Takara T., Yamamoto K., Suzuki N., Shimoda H. Seaberry extract with ursolic acid improves anxiety about urinary dysfunction in Japanese adults. Functional Foods Health and Disease, 7, 901-912 (2017).

コメ胚芽発酵エキス筋肉増加Tanaka M., Yoshino Y., Takeda S. Shimoda H., Tsumura K., Shimazawa M., Hara H. Fermented rice germ extract alleviates morphological and functional damage to murine gastrocnemius muscle by inactivation of AMP-activated protein kinase. J. Med. Food., 20, 969-980 (2017).
菊の花尿酸値Hirano M., Takeda S., Hitoe S., Shimoda H. Luteorin-rich chrysanthemum flower extract suppresses baseline serum uric acid in Japanese subjects with mild hyperuricemia. Integrative Mol. Med., 4 (2), 1-5 (2017).
γ-オリザノール安全性Moon S.H., Kim D., Shimizu N., Okada T., Hitoe S., Shimoda H. Ninety-day oral toxicity study of rice-derived γ-oryzanol in Sprague-Dawley rats. Toxicol. Reports, 4, 9-18 (2017).

1)Toda K., Takeda S., Hitoe S., Nakamura S. Matsuda H., Shimoda H. Enhancement of energy production by black ginger extract containing polymethoxy flavonoids in myocytes through improving glucose. J. Natur. Med. 70, 163-172 (2016).

2)Toda K., Hitoe S., Takeda S., Shimoda H. Black ginger extract increases physical fitness performance and muscular endurance by improving inflammation and energy metabolism. Helioyon 2: e00115 (2016).

3)Toda K., Kohatsu M., Takeda S., Hitoe S., Shimizu N., Shimoda H. Enhancement of physical fitness by black ginger extract rich in polymethoxyflavones: a double-blind randomized crossover trial. Integrative Mol. Med. 3, 628-634 (2016).

コプリーノ抗酸化・抗炎症Asahi T., Wu Xiaohong, Shimoda H., Harada E., Kanno T., Nakamura Y., Kato Y., Osawa T. A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation related DNA halogenation. Biosci. Biothechnol. Biochem. 80, 313-317 (2016).

Shimoda H., Hitoe S., Nakamura S., Matsuda H. Purple tea and its extract suppress diet-induced fat accumulation in mice and human subjects by inhibiting fat absorption and enhancing hepatic carnitine palmitoyltransferase expression. Int. J. Biomed. Sci. 11, 67-75 (2015).


1) Tanaka J., Kadekaru T., Ogawa K., Hotoe S., Shimoda H., Hara H. Maqui berry (Aristoterlia chinensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light. Food Chem. 139, 129-137 (2013).

2) Nakamura S., Tanaka J., Imada T., Shimoda H., Tsubota K. Delphinidin 3,5-O-digulucoside, a constituent of the maquiberry (Aristotelia chilensis) anthocyanin, restores teat secretion in a rat dry eye model. J. Functional Foods 10, 346-354 (2014).

3)Hitoe S., Tanka J., Shimoda H. MaquiBrightTM standardized maqui berry extract significantly increases tear fluid production and ameliorates dry eye-related symptoms in a clinical pilot trial. Panminerva Med. 56, suppl. 1 to 3, 1-6 (2014).

4) Yamashita S., Suzuki N., Yamamoto K., Iio S., Yamada T. Effects of MaquiBright® on improving eye dryness and fatigue in humans: A randomized, double-blind, placebo-controlled trial. J. Trad. Comple. Med. 9, 172-178 (2019).

ジュンサイ抗肥満,ヒアルロン酸増加Shimoda H., Nakamura S., Hitoe S., Terazawa S., Tanaka J., Matsumoto T., Matsuda H. Anti-adipogenic polyphenols of water shield suppress TNF-a-induced cell damage and enhance expression of HAS2 and HAPB2 in adiponectin treated dermal fibroblasts. Natur. Products Chem. Res. 2:5 (2014).
温州ミカン美白Shimoda H., Shan S.H., Tanaka J., Maoka T., Beta-Cryptoxantin suppressed UVB-induced melanogenesis in mouse: involvement of the inhibition of prostaglandin E2 and melanocyte-stimulating hormone pathway. J. Pharmacy Pharmacol. 64, 1165-76 (2012).